Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping.
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid.
The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors.
Nuclear localization of NPR1 is required for activation of PR gene expression.
Genes controlling expression of defense responses in Arabidopsis--2001 status.
Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance.
Benzothiadiazole-induced priming for potentiated responses to pathogen infection, wounding, and infiltration of water into leaves requires the NPR1/NIM1 gene in Arabidopsis.
In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis.
NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol.
The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1.
An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance.
Staphylococcus aureus pathogenicity on Arabidopsis thaliana is mediated either by a direct effect of salicylic acid on the pathogen or by SA-dependent, NPR1-independent host responses.
Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance.
Major signaling pathways modulate Arabidopsis glucosinolate accumulation and response to both phloem-feeding and chewing insects.
Conserved requirement for a plant host cell protein in powdery mildew pathogenesis.
The coactivator function of Arabidopsis NPR1 requires the core of its BTB/POZ domain and the oxidation of C-terminal cysteines.
Pathogen-associated molecular pattern recognition rather than development of tissue necrosis contributes to bacterial induction of systemic acquired resistance in Arabidopsis.
ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis.
NPR1 preferentially binds to the DNA-inactive form of Arabidopsis TGA2.
Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity.
Evidence for network evolution in an Arabidopsis interactome map.
NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants.
Metabolic and transcriptomic changes induced in Arabidopsis by the rhizobacterium Pseudomonas fluorescens SS101.
The BLADE-ON-PETIOLE genes of Arabidopsis are essential for resistance induced by methyl jasmonate.
Arabidopsis acyl-CoA-binding protein ACBP3 participates in plant response to hypoxia by modulating very-long-chain fatty acid metabolism.
Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses.
Extracellular ATP Shapes a Defense-Related Transcriptome Both Independently and along with Other Defense Signaling Pathways.
Extensive signal integration by the phytohormone protein network.
Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
Structural basis of NPR1 in activating plant immunity.
Characterization of a salicylic acid-insensitive mutant (sai1) of Arabidopsis thaliana, identified in a selective screen utilizing the SA-inducible expression of the tms2 gene.
The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats.
Deep research on NPR1 function
Falcon (Edison Scientific) deep research report on Arabidopsis thaliana NPR1 (UniProt P93002): salicylic-acid-responsive nucleo-cytoplasmic transcriptional co-regulator of systemic acquired resistance
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"NPR1)** is currently understood as a central node in **salicylic acid (SA)-mediated immunity**, functioning as a **transcriptional co-regulator** required for induction of SA-responsive defense genes such as **PR1** and for **systemic acquired resistance (SAR)**"
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"NPR1 contains a **BTB/POZ domain** and **four ankyrin repeats**, consistent with a primary role in **protein–protein interactions** rather than DNA binding (goyal2024analysisofthe pages 26-29, kim2023salicylicacidand pages 2-4). Consistent with this, NPR1 (and NPR3/4) are described as lacking DNA-binding domains and acting through transcription factors, particularly the **bZIP/TGA family**"
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"NPR1 interacts with **TGA transcription factors** to activate SA-inducible promoters such as **PR1**, functioning as a coactivator that enables robust PR gene induction"
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"NPR1 is best described as a **nucleo-cytoplasmic** protein whose function is executed primarily in the **nucleus** (transcriptional co-regulation), but whose activation state is controlled in the **cytosol**."
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"In uninduced conditions, NPR1 can exist as **cytosolic oligomers stabilized by intermolecular disulfide bonds** involving **Cys82 and Cys216**"
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"Immune induction with SA is associated with **redox changes** that reduce disulfides, producing monomeric NPR1 that **translocates to the nucleus**"
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"NPR1 is positioned as a core effector of SA signaling required for PR gene expression and broad-spectrum resistance"
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"the 2023 SA-transport/SAR review describes **NPR3/NPR4 as SA receptors and CRL3 substrate adaptors** that can mediate NPR1 polyubiquitination/degradation, with SA disrupting NPR1–NPR4 interaction and thereby stabilizing/activating NPR1"
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"proteasome-mediated turnover of nuclear NPR1** is integral to its coactivator function; ubiquitination is described as initiated at an N-terminal **IκB-like phosphodegron** requiring **Ser11/Ser15 phosphorylation**"
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"NPR1 (P93002)** is a **salicylic-acid-responsive nucleo-cytoplasmic transcriptional co-regulator** that controls **SA-induced defense gene expression (e.g., PR1)** and **systemic acquired resistance** by partnering with **TGA transcription factors** in the nucleus"
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes.