Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally.

EYA4, a novel vertebrate gene related to Drosophila eyes absent.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.

Eya4-deficient mice are a model for heritable otitis media.

Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish.

Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus.

Human Protein Atlas EYA4 subcellular localization

UniProtKB O95677 (EYA4_HUMAN) curated record