Falcon deep research report for CDK4
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27.
Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb.
A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95.
Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.
Self-assembling protein microarrays.
Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.
Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
A human protein-protein interaction network: a resource for annotating the proteome.
Towards a proteome-scale map of the human protein-protein interaction network.
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells.
Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells.
C-terminal phosphorylation controls the stability and function of p27kip1.
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.
Functional characterization of human PFTK1 as a cyclin-dependent kinase.
A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6.
Proteomic analysis of p16ink4a-binding proteins.
Sulindac suppresses beta-catenin expression in human cancer cells.
Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.
Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.
The structure of CDK4/cyclin D3 has implications for models of CDK activation.
Crystal structure of human CDK4 in complex with a D-type cyclin.
Shifted Transversal Design smart-pooling for high coverage interactome mapping.
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.
TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.
Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility.
Next-generation sequencing to generate interactome datasets.
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.
A directed protein interaction network for investigating intracellular signal transduction.
Toward an understanding of the protein interaction network of the human liver.
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
The protein interaction landscape of the human CMGC kinase group.
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.
A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
Widespread macromolecular interaction perturbations in human genetic disorders.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
Architecture of the human interactome defines protein communities and disease networks.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
CDK4/6 inhibitors dephosphorylate RNF26 to stabilize TSC1 and increase the sensitivity of ccRCC to mTOR inhibitors.
A comprehensive two-hybrid analysis to explore the Legionella pneumophila effector-effector interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.
Growth suppression by p16ink4 requires functional retinoblastoma protein.
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.
Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.
Cyclin-binding motifs are essential for the function of p21CIP1.
New functional activities for the p21 family of CDK inhibitors.
Interaction between Cdc37 and Cdk4 in human cells.
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
Association of INK4 family proteins with CDK4/6
Generic Transcription Pathway
CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77
CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)
PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm
Activated PTK6 binds CDKN1B
PTK6 phosphorylates CDKN1B
Formation of CDK4/6:CCND complexes
Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
CDK4 phosphorylates RUNX2
p16INK4A mutants do not bind CDK4
p16INK4A mutants do not bind CDK4,CDK6
CDK4 inhibitors bind CDK4
CDK4:CCND1 phosphorylates SPOP