glmR (PA5550, Q9HT24) review notes

DeoR-family transcriptional repressor, 257 aa: N-terminal HTH DeoR-type domain
(Pfam HTH_DeoR, residues 7-62) and C-terminal DeoR sensor domain (Pfam DeoRC,
NagB/RpiA-like fold, the effector-binding module of the family). PANTHER
PTHR30363 (SrlR-related). Unreviewed UniProt entry. Located between glmS
(PA5549) and glmU (PA5552).

Literature (no deep-research provider available; own reading)

Ramos-Aires et al. 2004 (abstract only; PMC353099 listed but the PubMed MCP
returned no full text on 2026-11-05). A Tn501 insertion in PA5550 (mutant
19A) gave broad antibiotic hypersusceptibility and a pleiotropic phenotype
[PMID:14982774 "Light microscopy of the mutant strain revealed abnormal
morphology characterized by large, filamentous cells."; "The drug
supersusceptibility of 19A was accompanied by loss of motility, reduced
resistance to osmotic and heat shock stress, and impaired growth at low
temperatures."]. GlmR represses glmS PMID:14982774.
The repression of glmS is the only target-level finding. Effects on cell
shape, motility and stress tolerance are consequences of a cell-envelope
defect in a pleiotropic mutant, not demonstrated regulatory roles of GlmR.
No other GlmR (PA5550) papers found; PubMed MCP search returned API errors.

PseudoCAP IBA-seed assessment

Other seeds' experimental support queried live in QuickGO on 2026-11-05.

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN000769142	GO:0006355 regulation of DNA-templated transcription	8	104 (29 taxa)	GO:0045892, IMP, PMID:14982774 (PseudoCAP)	SOUND	Abstract states GlmR represses glmS transcription; DeoR-family HTH domain agrees. Descendant term supports the node term.	E. coli GlpR P0ACL0 (IDA), SrlR P15082 (IDA), DeoR P0ACK5 (IMP), AgaR P0ACK2 (IMP), YciT P76034 (IMP), CsqR P32144 (IEP), L. lactis LacR P0A0Q0 (IMP)	Yes; several E. coli IDA/IMP seeds

No GO_CENTRAL defect.

Other PseudoCAP rows from the same paper (not seeds)

term	verdict	defect
GO:0045724 positive regulation of cilium assembly	WRONG	PSEUDOCAP WRONG_TERM, CONFIRMED: a cilium is by GO definition a eukaryotic organelle, so the term cannot apply to a bacterium. The underlying observation is loss of motility of a pleiotropic mutant.
GO:2000147 positive regulation of cell motility	INDIRECT-PHENOTYPE	PSEUDOCAP WRONG_TERM, PROBABLE: the abstract states loss of motility alongside filamentation and stress sensitivity, i.e. a general envelope defect; no flagellar target is reported.
GO:0032885 regulation of polysaccharide biosynthetic process	INDIRECT-PHENOTYPE	PSEUDOCAP WRONG_TERM, SUSPECTED (CHECK): the abstract only says glmS repression is "possibly affecting" precursor pools; the full text could contain measurements.