Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster.
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The discovery study reported five differentially spliced GLIPR1L2 isoforms.
"GLIPR1L1 has two and GLIPR1L2 has five differentially spliced isoforms."
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GLIPR1L2 was detected in several human tissues rather than only testis.
"GLIPR1L2 is expressed in different types of tissues, including prostate and bladder."
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The study identified GLIPR1L2 transcription as p53 responsive.
"Like hRTVP-1, GLIPR1L1 and GLIPR1L2 are p53 target genes."
Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding.
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This family study experimentally characterized mouse Glipr1l1, not Glipr1l2, so its sperm-localization evidence cannot be treated as direct GLIPR1L2 evidence.
"Herein we cloned mouse Glipr1l1 and have shown it has a testis-enriched expression profile."
GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse.
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The direct IZUMO1-complex evidence underlying the family adaptor model is specific to mouse GLIPR1L1.
"At least two of these complexes contain IZUMO1 in partnership with GLI pathogenesis-related 1 like 1 (GLIPR1L1)."
Mouse genome engineering uncovers 18 genes dispensable for male reproduction.
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Glipr1l2/GLIPR1L2 is highly expressed in mouse and human male reproductive tissues.
"Glipr1l1, Glipr1l2, Izumo4, Slc22a16, Spmip2, Tex51, Tmco2, Triml1, and Triml2 are highly expressed in mouse and human testis and epididymis"
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Combined deletion of mouse Glipr1l1, Glipr1l2, and Glipr1l3 did not produce the measured male-reproductive phenotypes.
"Glipr1l1‐3 KO males exhibited no anomalies in their testis weight, testis and epididymis histology, or sperm morphology and motility"
UniProtKB record for human GLIPR1L2 (Q4G1C9)
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GLIPR1L2 is a reviewed 344-amino-acid human protein.
"Reviewed; 344 AA."
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UniProt predicts a single transmembrane helix at residues 254–274.
"FT TRANSMEM 254..274"
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UniProt assigns an SCP/CAP domain at residues 58–192.
"FT DOMAIN 58..192"
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UniProt reports highest GLIPR1L2 expression in testis.
"CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Detected in prostate,"
Manual literature and annotation review notes for human GLIPR1L2
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No specific molecular activity or biological process is established for GLIPR1L2.
"No specific molecular activity or biological process is currently established strongly enough for a positive core GO assertion."
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The PAINT molecular-adaptor annotation is an unsafe transfer from mouse Glipr1l1.
"The only PAINT experimental seed is mouse Glipr1l1, whose adaptor-like activity is tied to an IZUMO1-containing sperm complex."
Manual literature synthesis for human GLIPR1L2 (Q4G1C9)
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The direct molecular activity and physiological process of GLIPR1L2 remain unknown despite support for generic membrane localization.
"GLIPR1L2 is an isoform-rich, testis-enriched single-pass membrane CAP-family protein whose direct molecular activity and physiological process remain unknown."