Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
Possible His to Asp phosphorelay signaling in an Arabidopsis two-component system.
Localization of the ethylene receptor ETR1 to the endoplasmic reticulum of Arabidopsis.
Mutational analysis of the ethylene receptor ETR1. Role of the histidine kinase domain in dominant ethylene insensitivity.
Characterization of mutants with reduced seed dormancy at two novel rdo loci and a further characterization of rdo1 and rdo2 in Arabidopsis.
Loss-of-function mutations in the ethylene receptor ETR1 cause enhanced sensitivity and exaggerated response to ethylene in Arabidopsis.
Effect of ethylene pathway mutations upon expression of the ethylene receptor ETR1 from Arabidopsis.
Canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission.
Sugar and hormone connections.
The Arabidopsis cupin domain protein AtPirin1 interacts with the G protein alpha-subunit GPA1 and regulates seed germination and early seedling development.
Analysis of combinatorial loss-of-function mutants in the Arabidopsis ethylene receptors reveals that the ers1 etr1 double mutant has severe developmental defects that are EIN2 dependent.
Effect of salt and osmotic stress upon expression of the ethylene receptor ETR1 in Arabidopsis thaliana.
Requirement of the histidine kinase domain for signal transduction by the ethylene receptor ETR1.
Ethylene-binding activity, gene expression levels, and receptor system output for ethylene receptor family members from Arabidopsis and tomato.
The etr1-2 mutation in Arabidopsis thaliana affects the abscisic acid, auxin, cytokinin and gibberellin metabolic pathways during maintenance of seed dormancy, moist-chilling and germination.
Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance.
Major signaling pathways modulate Arabidopsis glucosinolate accumulation and response to both phloem-feeding and chewing insects.
Potato homologs of Arabidopsis thaliana genes functional in defense signaling--identification, genetic mapping, and molecular cloning.
Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis.
Subcellular co-localization of Arabidopsis RTE1 and ETR1 supports a regulatory role for RTE1 in ETR1 ethylene signaling.
Ethylene signaling: identification of a putative ETR1-AHP1 phosphorelay complex by fluorescence spectroscopy.
Heteromeric interactions among ethylene receptors mediate signaling in Arabidopsis.
Glucosinolate metabolites required for an Arabidopsis innate immune response.
EIN2, the central regulator of ethylene signalling, is localized at the ER membrane where it interacts with the ethylene receptor ETR1.
Subcellular localization and in vivo interactions of the Arabidopsis thaliana ethylene receptor family members.
Ethylene signaling regulates accumulation of the FLS2 receptor and is required for the oxidative burst contributing to plant immunity.
Molecular association of the Arabidopsis ETR1 ethylene receptor and a regulator of ethylene signaling, RTE1.
Histidine kinase activity of the ethylene receptor ETR1 facilitates the ethylene response in Arabidopsis.
Plant vascular cell division is maintained by an interaction between PXY and ethylene signalling.
The ethylene response mediator ETR1 from Arabidopsis forms a disulfide-linked dimer.
Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators.
Interactions among the subunits of the G protein involved in Saccharomyces cerevisiae mating.
Ethylene-binding sites generated in yeast expressing the Arabidopsis ETR1 gene.
Histidine kinases in signal transduction pathways of eukaryotes.
Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors.
Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana.
A copper cofactor for the ethylene receptor ETR1 from Arabidopsis.
Deep research on ETR1 function
Falcon (Edison Scientific) deep research report: Arabidopsis thaliana ETR1 (UniProt P49333) functional annotation
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"In the absence of ethylene, receptor signaling promotes activity of the downstream kinase **CTR1**, suppressing the pathway; ethylene binding inactivates receptor output and relieves CTR1-mediated inhibition, enabling downstream EIN2-dependent signaling."
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"Ethylene binding requires a **Cu(I)** cofactor associated with the **N-terminal transmembrane sensor domain**."
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"Ethylene perception for ETR1 occurs at an **ER-associated membrane** (endomembrane system) rather than the plasma membrane, consistent with the receptor’s N-terminal multi-pass TM region and the localization of downstream pathway components."
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"ETR1 contains a functional **histidine kinase** region in biochemical assays"
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"subsequent genetics summarized in later work indicate that **canonical transmitter-domain histidine kinase activity is not required** for ethylene signal transmission (i.e., receptor signaling can proceed without it)"
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"A **copper cofactor is required** for ethylene binding at the N-terminal transmembrane region. The copper transporter **RAN1** is implicated in copper delivery to ethylene receptors"
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"Azhar et al. (2023) highlight a conserved **Asp25** as critical for high-affinity binding and signaling coupling"
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"Recent evidence supports **1 Cu per ETR1 monomer** (2 copper sites per dimer), providing a mechanistic basis for multiple binding site hypotheses and informing modern structural modeling."