Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly.

Six3 and Six6 activity is modulated by members of the groucho family.

The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas.

Direct interaction of geminin and Six3 in eye development.

Mutations in the human SIX3 gene in holoprosencephaly are loss of function.

Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells.

Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.

Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.

Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye.

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.

Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly.

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.

Six3 is required for ependymal cell maturation.

Six3 controls the neural progenitor status in the murine CNS.

Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.

Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter.

Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos.

Repression of Six3 by a corepressor regulates rhodopsin expression.