Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
CBS-derived H2S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB
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VC1061 is the principal enzyme for cysteine-derived H2S production in V. cholerae
"The results indicate that deletion of cbs is critical in reducing H2S production from cysteine in V. cholerae"
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CBS-derived H2S protects V. cholerae from oxidative stress
"deletion of cbs led to a 10-fold reduction in viability compared to the wild-type under intense H2O2 stress"
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H2S enhances catalase activity at post-translational level
"CBS-derived H2S enhances catalase activity in V. cholerae"
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CBS-derived H2S facilitates host colonization under high ROS conditions
"In the high ROS model, the cbs mutant (Δcbs) was outcompeted by wild-type (WT)"
Deep research summary for cds1 (VC1061) in Vibrio cholerae
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VC1061 is the principal enzyme for cysteine-derived H2S production
"Among the mutants of CBS candidates, only Δvc1061 showed a significant reduction in H2S production from cysteine"
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CBS is the key enzyme for H2S production in V. cholerae
"CBS is the key enzyme for H2S production in V. cholerae"
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CBS-derived H2S protects V. cholerae from oxidative stress via catalase activation
"Endogenous H2S driven by cbs/VC1061 protects V. cholerae from H2O2"
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Cysteine desulfhydrase reaction produces H2S, pyruvate, and ammonia
"The canonical cysteine desulfhydrase reaction yields H2S + pyruvate + NH3 from L-cysteine"
UniProt entry for Q9KT44 (Cds1, Vibrio cholerae)
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Protein is localized to cytoplasm
"SUBCELLULAR LOCATION: Cytoplasm"
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Enzyme is a PLP-dependent lyase
"Lyase"
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PLP binding site at Lys54
"N6-(pyridoxal phosphate)lysine"
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Catalytic reaction produces H2S, pyruvate, and ammonia
"L-cysteine + H2O = hydrogen sulfide + pyruvate + NH4(+)"