Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
The Prc and RseP proteases control bacterial cell-surface signalling activity.
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Prc removes the periplasmic anti-sigma domain, and RseP then removes the transmembrane domain to generate the active ECF sigma factor.
"Prc, which removes the periplasmic anti-sigma domain, and RseP, which subsequently removes the transmembrane domain and thereby generates the ECF active transcriptional form."
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Prc and RseP also act in classical CSS systems.
"We furthermore demonstrate the role of these proteases in the regulation of classical CSS systems"
The Pseudomonas aeruginosa periplasmic protease CtpA can affect systems that impact its ability to mount both acute and chronic infections.