GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:32156170

Biosynthesis and biology of mammalian GPI-anchored proteins.

PIGM (GPI-MTI) adds the first GPI mannose and functions in association with PIGX, which stabilizes PIGM; the core GPI is assembled on the ER membrane.

Reactome:R-HSA-162830

glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

Reactome reaction for the first-mannose addition to glucosaminyl-acyl-PI, catalyzed by a complex of PIG-M and PIG-X at the lumenal surface of the ER membrane.

file:human/PIGX/PIGX-uniprot.txt

UniProtKB Q8TBF5 PIGX record

UniProt describes PIGX as the stabilizing subunit of the GPI-mannosyltransferase I complex (with PIGM) that probably acts by stabilizing PIGM, a single-pass type I ER membrane protein participating in GPI-anchor biosynthesis.