Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

The fifth adaptor protein complex.

Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.

Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease.

Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval.

Structural basis for membrane remodeling by the AP5-SPG11-SPG15 complex.

Bi-allelic variants in three genes encoding distinct subunits of the vesicular AP-5 complex cause hereditary macular dystrophy.

A novel protein, MUDENG, induces cell death in cytotoxic T cells.

MUDENG is cleaved by caspase-3 during TRAIL-induced cell death.

Characterization of MUDENG, a novel anti-apoptotic protein.

BAX is an essential key mediator of AP5M1-induced apoptosis in cervical carcinoma cells.

MUDENG, a component of adaptor complex 5, mediates TRAIL- and TMZ-triggered apoptosis in glioblastoma (GBM) via multiple pathways.

Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.

UniProtKB Q9H0R1 (AP5M1_HUMAN) flat-file record

AP5M1 bioinformatics - mu2 cargo-pocket mapping and sequence checks

Affinage mechanistic annotation for AP5M1 (human)