LAG1 notes (P38703, YHL003C)

• Function: catalytic subunit (redundant with LAC1) of acyl-CoA dependent ceramide synthase; C26-CoA + PHS/DHS -> ceramide [UniProt:P38703]; PMID:11387200; PMID:11694577.
• Purified enzyme: PMID:15692566; third subunit Lip1 PMID:15692566.
• Location: ER membrane PMID:11694577; cortical + nuclear ER, PHS preference [UniProt:P38703].
• GO:0050291 (sphingosine N-acyltransferase) is the only GO MF for CerS; accepted despite sphingosine wording (yeast lacks sphingosine). No VLC-specific CerS GO term exists (EC 2.3.1.297) - possible ontology gap.
• Decisions: 6 protein-binding IPIs REMOVE (complex membership captured by GO:0061576); all other 19 ACCEPT.