Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Regulation of integrin-mediated T cell adhesion by the transmembrane protein tyrosine phosphatase CD45.
Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45.
SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription.
Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase.
The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production.
The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.
Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification.
Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation.
Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production.
CD45: direct and indirect government of immune regulation.
Phenotypical and functional alterations in the mucosal immune system of CD45 exon 9 KO mice.
CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production.
Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1.
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.
The role of CD45 in the activation, proliferation and differentiation of human B lymphocytes.
Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Association of CD2 and CD45 on human T lymphocytes.
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
CD45 regulates homing and engraftment of immature normal and leukemic human cells in transplanted immunodeficient mice.
The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.
Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.
The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.
Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase.
Structural variants of human T200 glycoprotein (leukocyte-common antigen).
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function.
Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.
Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro.
CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion.
Dephosphorylation of Lck-pY505 by CD45
SEMA4D interacts with CD45
Exocytosis of secretory granule membrane proteins
Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease.
-
Compound heterozygous PTPRC mutations cause SCID with few, unresponsive T cells and declining immunoglobulin levels.
"Thus, CD45 deficiency in humans results in T- and B-lymphocyte dysfunction."
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.
-
CD45 directly dephosphorylates and binds JAKs and negatively regulates cytokine receptor signaling.
"In vitro, CD45 directly dephosphorylates and binds to JAKs."
The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.
-
CD45 acts as a rheostat, differentially dephosphorylating LCK pTyr505 and pTyr394.
"These results are explained by a rheostat mechanism whereby CD45 differentially regulates the negatively acting pTyr-505 and positively acting pTyr-394 p56(lck) tyrosine kinase phosphorylation sites."
CD45 functions as a signaling gatekeeper in T cells.
-
CD45 both maintains a regulatable pool of active LCK and suppresses zeta-chain phosphorylation, filtering weak signals.
"Acute inhibition of Csk revealed that CD45 suppressed ζ-chain phosphorylation and was necessary for a regulatable pool of active Lck, thereby interconnecting the activating and suppressive roles of CD45 that tune antigen discrimination."
The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor.
-
Size-based exclusion of the CD45 ectodomain from ligated TCR prevents CD45 from inhibiting TCR triggering.
"Our results suggest that the large ectodomains of CD45 and CD148 modulate their inhibitory effect by enabling their passive, size-based segregation from ligated TCR, supporting the kinetic-segregation model of TCR triggering."
Orientation-dependent CD45 inhibition with viral and engineered ligands.
-
CD45 has no known physiological ligand, but extracellular dimerizing ligands such as adenovirus E3/49K inhibit its phosphatase activity.
"The adenovirus E3/49K protein has taught us that, despite a lack of a known ligand, CD45 activity can be modulated by extracellular dimerizing ligands that perturb its phosphatase activity and alter T cell responses."
A deletion in the gene encoding the CD45 antigen in a patient with SCID.
Falcon deep research report for human PTPRC
[Peculiarities of dephosphorylation reaction catalyzed by purified protein tyrosine phosphatase CD45 from thymocytes of intact and exposed to ionising radiation rats].