Gene Ontology annotation through association of InterPro records with GO terms

The family includes structural N-DRC subunits that help assemble associated inner dynein arms.

Annotation inferences using phylogenetic trees

The human DRC2 lineage inherits conserved axonemal localization, movement regulation, cell motility and arm-assembly assertions.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Flagellar localization is compatible with the mature N-DRC pool in respiratory cilia and sperm tails.

PMID:24094744

Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.

Human CCDC65 truncations disrupt nexin links and ciliary beating; algal FAP250 mutation and genomic rescue establish N-DRC and associated inner-arm assembly participation.

PMID:29257953

Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.

A tagged human CCDC65 construct localizes at the ciliary base with a basal-body marker in IMCD3 cells.

PMID:34169321

Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse.

Tagged DRC1 co-precipitates DRC2, consistent with their structural association in the N-DRC.

PMID:37258679

Axonemal structures reveal mechanoregulatory and disease mechanisms.

DRC2 is a structural N-DRC component in the human respiratory-axoneme inventory; algal DRC1–DRC2 coiled coils contribute to the complex scaffold.

PMID:17089017

Cloning and characterization of a novel sperm tail protein, NYD-SP28.

Endogenous human NYD-SP28 localizes along the sperm tail and in spermatogenic-cell cytoplasm; the capacitation-associated gel shift does not identify a specific modification or mechanism.

PMID:21700706

Building blocks of the nexin-dynein regulatory complex in Chlamydomonas flagella.

Algal proteomics identifies FAP250 as DRC2 and links its abundance and phosphorylation patterns to N-DRC mutant backgrounds.

PMID:20876659

CMF70 is a subunit of the dynein regulatory complex.

Trypanosome CMF70/DRC2 associates with the axoneme and trypanin-containing regulatory complex, and its depletion perturbs motility.

file:human/DRC2/DRC2-uniprot.txt

UniProtKB Q8IXS2: dynein regulatory complex subunit 2

The displayed and alternative products contain 484 and 497 residues, with an alternative C-terminal segment in the latter.