GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10339406

Genetic and structural characterization of the human mitochondrial inner membrane translocase.

Characterized the human TIM23/TIM17/TIM44 inner-membrane translocase that drives presequence import in cooperation with mtHSP70.

PMID:12592411

Characterization of the human heart mitochondrial proteome.

Detected DNAJC19/TIM14 in the human heart mitochondrial proteome by mass spectrometry.

PMID:16055927

Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition.

Human genetic mapping, segregation and RNA analysis link DNAJC19 exon 4 skipping to DCMA syndrome. The predicted 47-residue truncation differs from the current annotated 91-residue splice product; impaired import is proposed from homology rather than directly measured.

PMID:19564938

The mitochondrial protein translocation motor: structural conservation between the human and yeast Tim14/Pam18-Tim16/Pam16 co-chaperones.

Purified soluble human DNAJC19 and PAM16 form a heterodimer with measured biophysical stability. The ATPase experiment uses yeast Pam18 and yeast mitochondrial Hsp70 with human Magmas; it does not directly assay human DNAJC19 activation.

PMID:20053669

Role of Magmas in protein transport and human mitochondria biogenesis.

Human DNAJC19 stimulates Mortalin (mtHSP70) ATPase activity, which is inhibited by the Magmas:DnaJC19 complex; DNAJC19 co-precipitates with the human TIM23 translocon (hTim44, hTim23, Magmas).

PMID:34800366

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

file:human/DNAJC19/DNAJC19-uniprot.txt

UniProt entry Q96DA6 (TIM14_HUMAN), Mitochondrial import inner membrane translocase subunit TIM14

Mitochondrial co-chaperone of the PAM complex; single-pass inner-membrane protein with matrix-side J-domain; stimulates ATP-dependent import; interacts with PHB2 (prohibitin complex) and TIMM16/PAM16; cause of DCMA syndrome.

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:24856930

DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.

file:human/DNAJC19/DNAJC19-evidence-guide.md

DNAJC19 source and evidence guide