Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods
Towards a proteome-scale map of the human protein-protein interaction network.
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis.
MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.
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CIAO1 is a component of the MMXD complex (MMS19-MIP18-XPD-CIAO1-ANT2)
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MMXD localizes to the mitotic spindle during mitosis
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Knockdown leads to improper chromosome segregation
Next-generation sequencing to generate interactome datasets.
MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
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MMS19 forms a complex with CIAO1, IOP1, and MIP18
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This complex facilitates Fe-S cluster transfer to DNA metabolism proteins
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MMS19 knockout is preimplantation lethal in mice
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.
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MMS19, MIP18, and CIAO1 form a tight core complex
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IOP1/CIAO3 is an external component
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CIAO1 binds IOP1
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
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CIAO1 associates with either CIAO2A or CIAO2B
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CIA2B-CIA1-MMS19 complex matures most cytosolic-nuclear Fe-S proteins
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CIA2A-CIA1 specifically matures ACO1/IRP1 and stabilizes IRP2
Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A proteome-scale map of the human interactome network.
The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins.
Architecture of the human interactome defines protein communities and disease networks.
CIAO3 protein forms a stable ternary complex with two key players of the human cytosolic iron-sulfur cluster assembly machinery.
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CIAO3, CIAO1, and CIAO2A form a stable [4Fe-4S]-bound ternary complex
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C-terminal [4Fe-4S] cluster of CIAO3 has structural role
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
CIAO1 loss of function causes a neuromuscular disorder with compromise of nucleocytoplasmic Fe-S enzymes.
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Biallelic CIAO1 loss-of-function causes MMDS10 (MIM 620960)
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Patients have proximal muscle weakness, respiratory insufficiency, learning difficulties
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CIAO1 loss destabilizes MMS19 and FAM96B
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Multiple nucleocytoplasmic Fe-S enzymes are compromised (POLD1, DPYD, etc.)
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Lentiviral CIAO1 restoration rescues all cellular defects
Multimodal cell maps as a foundation for structural and functional genomics.
Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1.
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Original identification of CIAO1 as a WT1-interacting protein
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CIAO1 modulates WT1 transactivation activity
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Does not affect WT1 DNA binding or repression activity
Deep research report on CIAO1 function
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CIAO1 is a WD40/beta-propeller protein and core component of the late-acting CIA machinery
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A conserved C-terminal tripeptide TCR motif encodes specificity for CIA client targeting
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CIAO1 loss-of-function variants cause a neuromuscular disorder with selective compromise of nucleocytoplasmic Fe-S enzymes