Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Combined Automated Annotation using Multiple IEA Methods.
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
The interferon stimulated gene 54 promotes apoptosis.
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Architecture of the human interactome defines protein communities and disease networks.
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Expression of IFN-induced genes
Deep research summary for IFIT2
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IFIT2 binds AU-rich RNA sequences
"IFIT2 displays a strong preference for binding to AU-rich double-stranded RNA"
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IFIT2 forms heterocomplexes with IFIT1 and IFIT3
"IFIT2 and IFIT3 homodimers dissociate to form a more stable heterodimer"
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IFIT2 promotes mitochondrial apoptosis
"IFIT2 functions as a promoter of mitochondrial apoptosis through a pathway dependent on BCL2 family proteins"