mut-15 (Q22061) review notes

Accession: UniProt has two unreviewed entries for T01C3.8: Q22061 (isoform a, 541 aa) and
E1B6U1 (isoform b, 472 aa). Q22061 is the longer canonical isoform and the one that
carries the GOA annotation (mutator focus IDA), so it is used here. E1B6U1 has no GO
annotations.

Deep research: falcon timed out (exit 137) and perplexity-lite is unavailable. No
deep-research file was generated.

Key facts with provenance

• MUT-15 is also called RDE-5 PMID:25635455 and has no recognizable domains PMID:30036386.
• It is recruited by MUT-16 PMID:30036386.
• It recruits the RDE-8 and NYN nucleases [PMID:30036386 "Since MUT-15 recruits NYN-1, NYN-2 and RDE-8"; "Localization of RDE-8 and NYN-1 to Mutator foci requires both mut-16 and mut-15."].
• It is needed for RDE-8 to engage target mRNA PMID:25635455.
• Secondary siRNAs are lost in mut-15 mutants PMID:30036386.

Decisions

• Mutator focus IDA: ACCEPT.
• NEW siRNA processing (scaffold case). Comparator check: MUT-16 and RDE-2 carry it.
• No MF asserted. A knowledge gap is recorded for its unknown molecular activity.