PITA context: AIP corresponds to PITA1 / AIP-related pituitary adenoma predisposition. UniProt frames PITA1 as multiple pituitary adenoma types rather than GH-only, listing "growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid- stimulating hormone (TSH)-secreting, and plurihormonal" tumors [file:human/AIP/AIP-uniprot.txt "Functional pituitary adenomas are further classified by the type of hormone they secrete"].
Local review status: AIP-ai-review.yaml was already marked COMPLETE before this batch review. I treated it as an existing review and did not rewrite it. The review's core functional picture is AIP as an HSP90/AHR co-chaperone/scaffold and cytosolic chaperone-like factor for mitochondrial preprotein import, supported by direct AIP/Tom20/preprotein evidence PMID:14557246 and AIP/HSP90/AHR-complex evidence in the existing YAML.
Follow-up on GO:0051082: the projects/UNFOLDED_PROTEIN_BINDING.md project explicitly classifies AIP as MODIFY -> GO:0051879 Hsp90 protein binding, not as a GO:0044183 protein folding chaperone replacement. I aligned the review to treat PMID:14557246 as support for mitochondrial preprotein import and a holdase-like assay result, but not as evidence that AIP's core MF should be broad protein-folding chaperone activity.
Proteostasis PN re-review: Falcon deep research is already present (AIP-deep-research-falcon.md), so I did not rerun deep research. The PN projection has two AIP-relevant outputs: GO:0031072 heat shock protein binding as a candidate addition from the HSP70-HSP90 joint co-chaperone branch, and GO:0003755 peptidyl-prolyl cis-trans isomerase activity as already in GOA from the FKBP-type PPIase branch [file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_gene_go_summary.tsv "AIP GO:0031072 heat shock protein binding more_specific_than_existing_goa"; file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_gene_go_summary.tsv "AIP GO:0003755 peptidyl-prolyl cis-trans isomerase activity already_in_goa_exact"].
Conservative PN decision: do not accept or retain the PPIase projection for AIP. AIP has an FKBP-like/PPIase-like domain, but direct biochemical evidence states that the PPIase-like region is enzymatically inactive PMID:19375531. I updated both GO:0003755 annotation reviews to record that the PN FKBP/PPIase classification is over-broad for AIP at gene level.
For the co-chaperone projection, the biology supports heat-shock-protein binding in a broad sense because AIP binds HSP90 through its TPR motif PMID:19375531 and binds Hsc70 in the mitochondrial preprotein import context PMID:14557246. However, the existing review already uses the more specific GO:0051879 Hsp90 protein binding as the preferred replacement for obsolete GO:0051082, so I did not add a broad GO:0031072 assertion. I added a curator question asking whether PN should propagate the broad heat-shock-protein binding term for AIP or prefer the more specific HSP90-binding recommendation.