Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

UniProtKB entry P22830 (HEMH_HUMAN), Ferrochelatase, mitochondrial

A molecular defect in human protoporphyria.

Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis.

Substrate interactions with human ferrochelatase.

The molecular defect of ferrochelatase in a patient with erythropoietic protoporphyria.

Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase.

A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase.

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Proteomic Analysis of Ferrochelatase Interactome in Erythroid and Non-Erythroid Cells.

Mammalian ferrochelatase. Expression and characterization of normal and two human protoporphyric ferrochelatases.

Site-directed mutagenesis and spectroscopic characterization of human ferrochelatase: identification of residues coordinating the [2Fe-2S] cluster.

FECH binds Fe2+ to PRIN9 to form heme

CLPXP binds mitochondrial matrix proteins

LONP1 degrades mitochondrial matrix proteins

LONP1 binds mitochondrial matrix proteins

CLPXP degrades mitochondrial matrix proteins