Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:14980719

RJLs: a new family of Ras-related GTP-binding proteins.

RJL-family proteins lack the conserved catalytic glutamine that coordinates GTP hydrolysis in Ras-superfamily GTPases, and their chordate orthologues are chimeras with C-terminal J domains predicted to recruit Hsc70.

PMID:24746703

Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression.

Nucleus-localized RBJ interacts with MEK/ERK and prolongs the duration of MEK/ERK activation; Rbj deficiency abrogates nuclear accumulation of MEK1/MEK2 and attenuates ERK1/2 activation, and RBJ is dysregulated in gastrointestinal cancers, acting as an oncogenic Ras-related small GTPase.

PMID:25416956

A proteome-scale map of the human interactome network.

PMID:32296183

A reference map of the human binary protein interactome.

file:human/DNAJC27/DNAJC27-uniprot.txt

UniProt entry Q9NZQ0 (DJC27_HUMAN), DnaJ homolog subfamily C member 27 (RBJ)

Chimeric Ras/Rab-like GTPase plus C-terminal J domain; binds GTP and (in GTP-bound form) MAP2K1, interacts with MAPK1 via N-terminal region; nuclear; activates the MEK/ERK pathway and can induce cell transformation when overexpressed.