sid-3 (Q10925) review notes

Deep research was skipped: falcon times out in this environment and perplexity-lite is unavailable.
This review relies on cached full-text papers (PMID:22912399, PMID:28874466, PMID:28874467).

• ACK-family non-receptor tyrosine kinase (kinase, SH3 and CRIB domains) PMID:22912399.
• Required in recipient cells for dsRNA import. Cell-autonomous RNAi is intact PMID:22912399.
• Kinase activity is required: the K139A mutant does not rescue PMID:22912399.
• Required for an early, pre-replication step of Orsay virus infection, and kinase activity is needed for this PMID:28874467.
• sid-3 mutants derepress STA-1-bound antiviral genes PMID:28874466.

Decisions:
- GO:0035194 (ncRNA-mediated PTGS, IMP): MODIFY to GO:0033227 dsRNA transport.
SID-3 is needed for dsRNA import, not for the silencing machinery.
- Plasma membrane IBA: kept as non-core. ACK kinases associate with membranes and vesicles, but
SID-3 has only been seen in the cytoplasm.
- NEW GO:0050687 negative regulation of defense response to virus (IMP, PMID:28874466). This matches
the module annoton.