Gene Ontology annotation through association of InterPro records with GO terms
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Deep research report for SLC26A11 ortholog in Pan paniscus
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SLC26A11 functions primarily as the lysosomal sulfate exporter, using the proton gradient as driving force
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SLC26A11 localizes predominantly to lysosomes with significant Lamp1 overlap (Manders coefficient 0.45-0.50) and minimal ER overlap (0.09-0.12)
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SLC26A11 exhibits dual transporter-channel function: electroneutral proton:sulfate/chloride exchange and chloride-selective channel conductance
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Bicarbonate and phosphate show minimal or no competition for the SLC26A11 substrate binding site
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Glu-320 acts as a pH-sensitive switch, increasing sulfate binding affinity approximately 50-fold at acidic pH