Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis.
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The recombinant human APRT was crystallized in complex with AMP, revealing a type I PRTase fold and providing the structural basis for DHA-urolithiasis-causing mutations. APRT is the only route for salvage of adenine from polyamine biosynthesis or diet.
"In mammals, adenine phosphoribosyltransferase (APRT, EC 2.4.2.7) is present in all tissues and provides the only known mechanism for the metabolic salvage of adenine resulting from the polyamine biosynthesis pathway or from dietary sources."
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Human adenine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme.
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Established the complete 179-residue amino acid sequence of human erythrocyte APRT, showing homology to E. coli xanthine-guanine phosphoribosyltransferase and an acetylated N-terminus.
"Human adenine phosphoribosyltransferase has sequence homology with xanthine-guanine phosphoribosyltransferase from Escherichia coli"
Exocytosis of secretory granule lumen proteins
APRT catalyzes the conversion of adenine to AMP
Defective APRT does not convert adenine to AMP