Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Bi-allelic variants in DNAH3 cause male infertility with asthenoteratozoospermia in humans and mice.

DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice.

Novel bi-allelic DNAH3 variants cause oligoasthenoteratozoospermia.

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

Axonemal structures reveal mechanoregulatory and disease mechanisms.

DNAH3 interacts with DNALI1 and is required for sperm flagellum function and male fertility.

Impact of DNAH3 deficiency on sperm energy metabolism and motility leading to asthenozoospermia†.

UniProt entry Q8TD57 (DNAH3)