GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:16809611

BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes.

Activated T-cell experiments establish IL2-site recognition and transcriptional activation. Abstract and selected primary Figure 5/Discussion text were read; this is not a complete-paper audit.

PMID:17245431

Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing.

CTIP2 associates with HDAC1/2 and SUV39H1 and supports HIV-1 promoter silencing. Selected primary Results and Discussion distinguish Sp1-mediated recruitment at this promoter from direct DNA recognition; the abstract phrase DNA-bound does not establish direct BCL11B contact. The canonical cache remains abstract-only; selected indexed primary text was additionally inspected.

PMID:23644491

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

Mouse discovery and human T-cell biochemical experiments support stable BCL11B SWI/SNF membership. The selected data do not establish exclusive membership in every tissue.

PMID:23752268

The functional interactome landscape of the human histone deacetylase family.

The human CEM T-cell HDAC interactome explicitly identifies BCL11B among HDAC1 interactions. Its exact HDAC2 supplementary pair remains unchecked; the HDAC2 functional refinement also uses the independent experiments in PMID:17245431.

PMID:27959755

Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B.

Human CD34 and zebrafish experiments connect BCL11B perturbation with progenitor positioning, chemokine responsiveness and T-cell development. The N441K variant alters target recognition, including gain of a new site, and retains p300 association.

PMID:28473536

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

Human transcription-factor SELEX provides the source of the curated DNA-binding assertion. The exact BCL11B motif/construct entry and a methylation preference were not independently established.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Two cell-line affinity-purification networks provide the interaction resource. The individual BCL11B–HDAC pairs and cell assignments were not inspected; their functional refinement also uses independent mechanistic evidence from PMID:17245431.

Reactome:R-HSA-9934021

Formation of neuronal progenitor BAF (npBAF)

The cached summary gives mouse neural-progenitor BAF context. It is not a direct human BCL11B localization experiment.

Reactome:R-HSA-9934024

SMARCA4, BCL11A,B-containing ATPase module binds SMARCC1:SMACC2 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1A:DPF2, PHF10

The cached assembly summary includes BCL11A/B and preserves unresolved BAF-subtype distribution. It does not give BCL11B ATPase activity.

file:human/BCL11B/BCL11B-uniprot.txt

UniProt entry for human BCL11B (Q9C0K0)

The UniProt record identifies BCL11B/CTIP2, nuclear localization, HDAC1/2 and SUV39H1 interaction partners, and two alternative products. Product-specific functional differences are not established here.