Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Nucleolar protein B23 has molecular chaperone activities.
Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.
Diverged nuclear localization of Werner helicase in human and mouse cells.
Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone.
The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype.
Nucleophosmin regulates the stability and transcriptional activity of p53.
Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR.
Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene.
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation.
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase.
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication.
Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation.
Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.
Nucleophosmin is essential for ribosomal protein L5 nuclear export.
Antiviral action of the tumor suppressor ARF.
Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication.
Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation.
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Detection and identification of transcription factors as interaction partners of alien in vivo.
The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA.
Physical and functional interaction between a nucleolar protein nucleophosmin/B23 and adenovirus basic core proteins.
The nucleocapsid protein of SARS-associated coronavirus inhibits B23 phosphorylation.
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.
Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation.
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.
Defining the membrane proteome of NK cells.
Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size.
Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.
The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Proteomic characterization of the human sperm nucleus.
Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length.
Toward an understanding of the protein interaction network of the human liver.
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Erythroid differentiation-associated gene interacts with NPM1 (nucleophosmin/B23) and increases its protein stability, resisting cell apoptosis.
PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex.
DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas.
Exploration of binary virus-host interactions using an infectious protein complementation assay.
Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells.
ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair.
Intrinsically disordered regions of nucleophosmin/B23 regulate its RNA binding activity through their inter- and intra-molecular association.
Interaction between nucleophosmin and HBV core protein increases HBV capsid assembly.
Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression.
A proteome-scale map of the human interactome network.
The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity.
Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.
Proteomics analysis identifies the ribosome associated coiled-coil domain-containing protein-124 as a novel interaction partner of nucleophosmin-1.
ARID3C Acts as a Regulator of Monocyte-to-Macrophage Differentiation Interacting with NPM1.
Systematic identification of post-transcriptional regulatory modules.
Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat.
Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis.
Association of Ran-GTP with importin-beta
Disassembly of the Rev-importin beta-B23:Ran-GTP complex
SUMOylation of NPM1 with SUMO2,3
SUMOylation of NPM1 with SUMO1
RSF complex binds the centromere
New CENPA-containing nucleosomes are deposited at the centromere
HJURP:CENPA complex localizes to the centromere
TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter
TFPA2A homodimer and NPM1 bind the NOP2 gene promoter
TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter
NPM1 binds TFAP2A homodimer
ALK mutants bind type I TKIs
Ligand-independent dimerization of ALK fusions
Autophosphorylation of ALK fusions
ALK mutants phosphorylate SHC1
ALK fusion proteins bind PLCG1
ALK fusions phosphorylate IRS1
PI3K synthesizes PIP3 downstream of ALK mutants
ALK mutants phosphorylate STAT3
ALK fusions phosphorylate PLCG1
ALK fusions phosphorylate FRS
ALK fusion proteins bind IRS
ALK mutants:p-3Y SHC binds GRB2
NPM1-ALK translocates to the nucleus
NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1
MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner
SARS-CoV-1 SUMO-p-N binds to NPM1
pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants
NPM1-ALK binds NPM1 and FOXM1
Nucleophosmin: A Nucleolar Phosphoprotein Orchestrating Cellular Stress Responses
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NPM1 is a modular protein with an N-terminal oligomerization domain, a central acidic/disordered region contributing to histone binding, and a C-terminal globular nucleic-acid-binding domain including nucleolar localization determinants (NoLS) and key aromatic residues (W288/W290).
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NPM1 is a major driver of nucleolar LLPS, forming homotypic droplets and heterotypic droplets with arginine-rich proteins and rRNA that help establish nucleolar GC structure and ribosome-production capacity.
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Oxidation and S-glutathionylation at Cys275 triggers NPM1 release from the nucleolus to the nucleoplasm during nucleolar stress responses.
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NPM1 participates in DNA damage responses and repair pathway execution, including scaffolding/interaction with DNA repair factors and regulation by phosphorylation states, and interacts with p53/HDM2 regulatory circuits in the context of stress and genome stability.
The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets
Targeting and Monitoring Acute Myeloid Leukaemia with Nucleophosmin-1 (NPM1) Mutation
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Common exon 12 frameshift mutations disrupt the C-terminal fold/NoLS (including loss of key aromatic residues W288/W290) and introduce/strengthen nuclear export, shifting NPM1 to the cytoplasm (NPM1c+), a hallmark visualizable by immunohistochemistry.
Criteria for Diagnosis and Molecular Monitoring of <i>NPM1</i>-Mutated AML
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NPM1-mutated AML is the largest molecular subgroup of adult AML, accounting for approximately 30-35% of adult cases and enriched in normal-karyotype AML (approximately 50-60%).
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NPM1 mutations are AML-specific and absent from preleukemic clonal hematopoiesis, making them particularly suitable MRD targets.