DYNC1H1 review notes

2026-09-27 (claude-code)

• Core function: catalytic heavy chain of cytoplasmic dynein 1; minus-end-directed microtubule motor
  PMID:21723285.
  Processive motility needs dynactin plus an activating adaptor PMID:24986880.
• Nucleokinesis: dynein pulls the nucleus toward the centrosome PMID:17618279;
  PMID:15173193.
  Human MCD variants PMID:22368300. Consistent with module assignment of GO:0008569.
• Decisions: all 56 GO:0005515 rows REMOVE (uninformative; LIS1, HTT, DISC1, CRACR2A etc.).
  "Positive regulation of intracellular transport" rows MODIFY to direct transport terms (dynein is the motor, not a regulator).
  "Positive regulation of mitotic SAC" (NAS, PMID:19229290) MODIFY to GO:1902426 deactivation of mitotic SAC
  PMID:19229290.
  "Regulation of mitotic spindle organization" (PMID:23027904) MODIFY to GO:0040001 establishment of mitotic spindle localization (the assay is spindle positioning).
  Azurophil granule lumen / extracellular region (Reactome) REMOVE; exosome HDA, RNA-binding HDA, cold-induced thermogenesis, male germ cell nucleus MARK_AS_OVER_ANNOTATED.
• Falcon deep research (arrived mid-review) agrees; cited for retrograde axonal transport and nuclear positioning.
• New cached PMIDs: 12730604, 21820100, 22368300, 29420470.