PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1.
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PHF23 overexpression impairs autophagy with decreased LC3B-II levels and weakened degradation of autophagic substrates
"the overexpression of PHF23 impaired autophagy, as characterized by decreased levels of LC3B-II and weakened degradation of endogenous and exogenous autophagic substrates"
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PHF23 knockdown results in enhanced autophagy
"knockdown of PHF23 resulted in opposite effects"
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PHF23 interacts with LRSAM1, an E3 ligase essential for ubiquitin-dependent autophagy against invading bacteria
"PHF23 interacts with LRSAM1, which is an E3 ligase key for ubiquitin-dependent autophagy against invading bacteria"
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PHF23 promotes ubiquitination and proteasomal degradation of LRSAM1
"PHF23 promotes the ubiquitination and proteasome degradation of LRSAM1"
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The PHD finger domain is required for interaction with LRSAM1
"the PHD finger of PHF23 is a functional domain needed for the interaction with LRSAM1"
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PHF23 is a negative regulator of autophagy via the LRSAM1 signaling pathway
"PHF23 is a negative regulator associated in autophagy via the LRSAM1 signaling pathway"