Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Role of cAMP-dependent protein kinase during growth and early development of Dictyostelium discoideum.
Interaction of gdt1 and protein kinase A (PKA) in the growth-differentiation-transition in Dictyostelium.
Regulated expression of the MADS-box transcription factor SrfA mediates activation of gene expression by protein kinase A during Dictyostelium sporulation.
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PKA activation during culmination induces srfA expression, linking PKA to late (spore) gene expression.
"PKA activation during culmination leads to the induction of the expression of srfA"
Galpha3 and protein kinase A represent cross-talking pathways for gene expression in Dictyostelium discoideum.
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PKA activity was measured directly by phosphorylation of the PKA-specific substrate Kemptide.
"PKA activity, measured by phosphorylation of the PKA-specific substrate Kemptide"
CulB, a putative ubiquitin ligase subunit, regulates prestalk cell differentiation and morphogenesis in Dictyostelium spp.
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PkaC promotes prestalk cell differentiation whereas CulB suppresses it.
"PkaC promotes prestalk cell differentiation, while CulB suppresses it"
Overexpression of Dd PK2 protein kinase causes rapid development and affects the intracellular cAMP pathway of Dictyostelium discoideum.
DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase.
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pkaC (DdPK3) encodes the PKA catalytic subunit; null cells lack PKA-specific kinase activity.
"DdPK3 null cells lack kinase activity that phosphorylates a PKA-specific substrate and is specifically inhibitable by recombinant cAMP-dependent protein kinase inhibitor"
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Properly regulated PKA activity is essential for culmination.
"properly regulated PKA activity is essential for culmination"
Hypertonic signal promotes stability of Dictyostelium spores via a PKA-independent pathway.
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Spore differentiation initiates with PKA-controlled rapid encapsulation of prespore cells.
"Differentiation of Dictyostelium spores initiates with rapid encapsulation of prespore cells under the control of cAMP-dependent protein kinase (PKA)"
Chemoattractant signaling in dictyostelium discoideum.
Molecular and functional analysis of the dictyostelium centrosome.
STAT signaling in Dictyostelium development.
The polyketide MPBD initiates the SDF-1 signaling cascade that coordinates terminal differentiation in Dictyostelium.
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SDF-1 signaling activates PKA via the adenylyl cyclase ACG to trigger further SDF-1 production during terminal differentiation.
"SDF-1 apparently acts through the adenylyl cyclase ACG to activate the cyclic AMP (cAMP)-dependent protein kinase A (PKA) and trigger the production of more SDF-1"
Robustness of self-organizing chemoattractant field arising from precise pulse induction of its breakdown enzyme: a single-cell level analysis of PDE expression in Dictyostelium.
Curcumin inhibits development and cell adhesion in Dictyostelium discoideum: Implications for YakA signaling and GST enzyme function.
An unusual adenosine cyclic 3',5'-phosphate-dependent protein kinase from Dictyostelium discoideum.
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The Dictyostelium PKA holoenzyme is a dimer of one regulatory and one catalytic subunit that dissociates on cAMP binding.
"The CAMP-dependent holoenzyme is a dimer consisting of one regulatory and one catalytic subunit"
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Catalytic activity and its inhibition by the regulatory subunit are pH-dependent.
"both the catalytic activity and its ability to be inhibited by addition of regulatory subunit are increased very strongly"
Adenylate cyclase A acting on PKA mediates induction of stalk formation by cyclic diguanylate at the Dictyostelium organizer.
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c-di-GMP induces stalk genes via ACA-produced cAMP acting on PKA; PKA activation bypasses the c-di-GMP requirement.
"PKA activation bypassed the c-di-GMP requirement for stalk gene expression"
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DgcA activates tip-expressed ACA, which then acts on PKA to induce stalk genes.
"DgcA activates tip-expressed ACA, which then acts on PKA to induce stalk genes"
Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.
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Cells lacking PKA have severe cAMP chemotaxis defects with impaired directional sensing.
"cells lacking PKA display severe chemotaxis defects, including impaired directional sensing"
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PKA controls chemoattractant signal transduction in part through regulation of RasG, Rap1 and TORC2.
"PKA controls chemoattractant signal transduction, in part, through the regulation of RasG, Rap1 and TORC2"
Curcumin affects gene expression and reactive oxygen species via a PKA dependent mechanism in Dictyostelium discoideum.
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The curcumin-induced transcriptional/ROS response is mediated in part by PKA.
"This transcriptionally regulated physiological response is mediated, in part, by the cyclic AMP-dependent protein kinase A (PKA)"
The physiological regulation of macropinocytosis during Dictyostelium growth and development.
The transcription factor Spores Absent A is a PKA dependent inducer of Dictyostelium sporulation.
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SpaA-dependent spore gene expression requires PKA and is stimulated by the PKA agonist 8Br-cAMP.
"SpaA dependent spore gene expression required PKA in vivo and was stimulated in vitro by the membrane-permeant PKA agonist 8Br-cAMP"
An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cells.
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AprA chemorepulsion uses a subset of cAMP chemoattraction pathways including protein kinase A.
"AprA uses a subset of chemoattraction signal transduction pathways including Ras, protein kinase A, target of rapamycin (TOR), phospholipase A, and ERK1"
Regulation of Dictyostelium early development genes in signal transduction mutants.
Protein kinase A is a positive regulator of spore coat gene transcription in Dictyostelium.
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A dominant PKA inhibitor in prespore cells greatly reduces cotB and cotC transcription.
"expression of a dominant inhibitor of the cAMP dependent protein kinase (PKA) in prespore cells greatly reduces the transcription rates of the cotB and cotC genes"
cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development.
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PKA activity is essential for aggregation, prespore gene induction and multicellular development.
"cAMP-dependent protein kinase (PKA) activity is essential for aggregation, induction of prespore gene expression and multicellular development"
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Constitutive PKA from a prespore promoter accelerates spore cell differentiation.
"Expression of PKAcat from the prespore promoter resulted in abnormal morphogenesis and accelerated spore cell differentiation"
An unusual catalytic subunit for the cAMP-dependent protein kinase of Dictyostelium discoideum.
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PkaC is the ~73 kDa catalytic subunit that copurifies with cAPK activity and associates with the regulatory subunit.
"PkaC copurifies with cAPK activity"
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PkaC is physically associated with the regulatory subunit.
"It is physically associated with the regulatory subunit"
Induction of terminal differentiation of Dictyostelium by cAMP-dependent protein kinase and opposing effects of intracellulr and extracellular cAMP on stalk cell differentiation.
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Cell-type-specific expression of the PKA catalytic subunit causes ectopic terminal differentiation.
"Expression of the catalytic (C) subunit of the cAMP-dependent protein kinase (PKA) of Dictyostelium under the control of heterologous, cell-type-specific promoters causes ectopic terminal differentiation"
Dual role of cAMP and involvement of both G-proteins and ras in regulation of ERK2 in Dictyostelium discoideum.
The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function.
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PKA is an important regulator of ERK2 activation and adaptation.
"Ras and cAMP-dependent protein kinase (PKA), are important regulators of ERK2 activation and adaptation"
A new spore differentiation factor (SDF) secreted by Dictyostelium cells is phosphorylated by the cAMP dependent protein kinase.
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Overexpression of the PKA catalytic subunit renders cells sporogenous.
"overexpression of the catalytic subunit of the cAMP dependent protein kinase (PKA), not only renders the cells sporogenous"
A molecular network that produces spontaneous oscillations in excitable cells of Dictyostelium.
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In the cAMP oscillator, a rise in internal cAMP activates PKA, which inhibits ERK2 and causes loss of CAR1 ligand binding.
"A rise in the internal concentration of cAMP activates protein kinase A such that it inhibits ERK2 and leads to a loss-of-ligand binding by CAR1"