aph-1 (Drosophila melanogaster, Q9VQG2) notes

Identity

• Seven-TM subunit of gamma-secretase; scaffold that binds nicastrin and stabilises the presenilin holoprotein during complex assembly.

Literature

• Discovery and conservation PMID:12110170; fly S2 RNAi PMID:12110170; PMID:12110170
• Stabilises Psn PMID:12660785; PMID:12660785.
• Reconstitution PMID:20421416.

Curation thoughts

• protein-macromolecule adaptor activity (IBA) fits the scaffolding role; core.
• Decisions on shared gamma-secretase terms made consistently with Nct and pen-2 (ectodomain proteolysis -> MODIFY; amyloid-beta formation -> non-core).

2026-10-12: why core_functions asserts no location

• The core location is given by in_complex: GO:0070765 gamma-secretase complex, which is part_of membrane. The two generic membrane rows are MODIFY'd to that complex.
• The only plasma membrane annotation is a NAS row (PMID:12110170), kept as non-core: gamma-secretase acts at the plasma membrane and in endosomes. A core location would have to come from a retained core row, and there is no experimental one. So, unlike Nct (which has IBA and HDA plasma membrane rows), no location is asserted rather than over-stating a non-core one.