Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000041

Gene Ontology annotation based on UniPathway vocabulary mapping

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

PMID:12754505

SOCS3 negatively regulates IL-6 signaling in vivo.

SOCS3 is the principal physiological negative regulator of IL-6/gp130 signaling in vivo; conditional Socs3 deletion prolongs STAT1 and STAT3 activation after IL-6 stimulation, whereas IFN-gamma responses are SOCS1-dependent.

PMID:19027008

The role of microtubule-associated protein 1S in SOCS3 regulation of IL-6 signaling.

MAP1S was identified as a novel SOCS3-interacting protein; the SOCS3-MAP1S interaction and microtubule integrity contribute to SOCS3 inhibition of IL-6/STAT3 signaling.

PMID:24728074

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.

High-throughput fluorescence-polarization SH2-domain interactome study; reports SOCS3 SH2 binding to phosphopeptides including c-Kit (KIT) and c-Met (MET).

PMID:25019494

MiR-221 accentuates IFN׳s anti-HCV effect by downregulating SOCS1 and SOCS3.

SOCS3 (with SOCS1) is a well-established inhibitor of the IFN/JAK/STAT pathway; miR-221 downregulates SOCS3, relieving JAK-STAT inhibition and enhancing the anti-HCV effect of IFN-alpha.

PMID:25203322

PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.

Reports a SOCS3-SNAI1 protein-protein interaction (IntAct) within an EMT/SNAIL-degradation study primarily focused on FBXO11.

PMID:25416956

A proteome-scale map of the human interactome network.

Systematic binary (Y2H) interactome map reporting SOCS3 interactions (e.g., YES1, KIAA1958).

PMID:27893700

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T(H)17 cells.

IL-6 trans-presentation by dendritic cells drives priming of pathogenic Th17 cells; SOCS3 is a feedback inhibitor within the IL-6/STAT3/Th17 axis.

PMID:32296183

A reference map of the human binary protein interactome.

Reference binary (Y2H) interactome map reporting SOCS3 interactions (e.g., YES1, TXK, BLK, KIAA1958).

PMID:9266833

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.

Cloning paper for human SSI-2 (SOCS2) and SSI-3 (SOCS3); SSI family members are cytokine-induced and act in negative feedback control of JAK-STAT signaling. Forced expression of SSI-3/SOCS3 suppressed the apoptotic effect of LIF.

PMID:9727029

Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.

SOCS family proteins are negative regulators of cytokine receptor signaling via the JAK/STAT pathway and interact with activated receptor tyrosine kinases (here IGF-IR).

PMID:15601820

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

SOCS-box proteins (including SOCS3) recruit substrates to the ECS (Elongin B/C-Cullin-Rbx) complex via Elongin B/C and associate specifically with Cul5-Rbx2, defining the SOCS-box E3 ubiquitin ligase module.

Reactome:R-HSA-1112755

SOCS3 binds IL6ST

Reactome:R-HSA-6785860

Expression of SOCS1

Reactome:R-HSA-6790041

Expression of STAT3-upregulated cytosolic proteins

Reactome:R-HSA-877269

SOCS-1 and SOCS-3 binds to p-JAK2

Reactome:R-HSA-8848110

SOCS3 binds activated PTK6

Reactome:R-HSA-8848178

STAT3 stimulates SOCS3 expression

Reactome:R-HSA-8952039

NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex

Reactome:R-HSA-8952044

AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex

Reactome:R-HSA-8955241

CAND1 binds cytosolic CRL E3 ubiquitin ligases

Reactome:R-HSA-8955289

COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes

Reactome:R-HSA-8956040

COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes

Reactome:R-HSA-9705738

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7

Reactome:R-NUL-1169195

SOCS binding to Ghr