Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
The ire1 and ptc2 genes involved in the unfolded protein response pathway in the filamentous fungus Trichoderma reesei.
-
T. reesei ire1 complements S. cerevisiae ire1 mutants
"The data presented demonstrates that the T. reesei genes can complement Saccharomyces cerevisiae mutants that are deficient in the corresponding homologues."
-
T. reesei IRE1 has intrinsic kinase activity (in vitro autophosphorylation)
"The T. reesei IREI protein has intrinsic kinase activity, as revealed by an in vitro autophosphorylation assay."
-
Overexpression of ire1 upregulates UPR target genes bip1 and pdi1
"Overexpression of ire1 in a T. reesei strain that expresses a foreign protein (laccase 1 from Phlebia radiata), results in up-regulation of the UPR pathway, as indicated by the increased expression levels of the known UPR target genes bip1 and pdi1."
-
HAC1 mRNA splicing observed upon ire1 overexpression
"Splicing of the mRNA encoding the transcription factor HAC1 is also observed."
Deep research report on IRE1 (Falcon/Edison Scientific Literature)
Focused OpenScientist report on fungal IRE1 stress-death and TRAF2-ASK1 transfers
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response.
UniProtKB G0RBE3 target protein record
IRE1 full-gene source and term-scope re-review notes
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity