Falcon deep research report for HSPA1L
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain.
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
A reference map of the human binary protein interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man.
HSF1-mediated gene expression
Heat Shock Protein Network - the Mode of Action, the Role in Protein Folding and Human Pathologies
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Describes the canonical HSP70 ATPase-driven allosteric cycle in detail: ATP binding promotes open SBD lid, hydrolysis promotes closure and higher client affinity, nucleotide exchange resets cycle. J-domain proteins deliver substrates and stimulate hydrolysis; NEFs (BAG proteins, HSP110) accelerate ADP-to-ATP exchange. HSPA1L function cannot be fully interpreted from sequence alone; context-specific co-chaperone availability drives functional specialization among paralogs.
Profiling the Hsp70 Chaperone Network in Heat-Induced Proteotoxic Stress Models of Human Neurons
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HSPA1L protein was induced approximately 2.5-3.5-fold in SH-SY5Y and differentiated SH-SY5Y neuronal cells under heat stress, with gene expression peaking at approximately 1 hour post-stress and protein at approximately 5-6 hours. Co-expression network analysis linked HSPA1L with PRKN (Parkin) and STUB1, connecting it to protein quality control pathways.
Silencing METTL3 Increases HSP70 Expression and Alleviates Fibrosis in Keratocytes
Genetic associations in ankylosing spondylitis - circulating proteins as drug targets and biomarkers
Causal associations of plasma proteins with lung squamous cell carcinoma risk: a proteome-wide Mendelian randomization and colocalization analysis
HSPA1L and HSPA1B gene polymorphisms and haplotypes are associated with idiopathic male infertility in Iranian population
Bioinformatics analysis and alternative polyadenylation in Heat Shock Proteins 70 (HSP70) family members