Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.
Functional dissection of Rab GTPases involved in primary cilium formation.
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.
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TBC1D14 has no detectable GAP activity on 47 Rabs; it binds active Rab11, localizes to recycling endosomes, and negatively regulates starvation-induced autophagosome formation.
"supporting the data that TBC1D14 has no GAP activity"
A reference map of the human binary protein interactome.
TBC1D14 binds RAB11 and ULK1
TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic.
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TBC1D14 bridges Rab11 and TRAPPIII (via TRAPPC8) and is required for RAB1 activation and ATG9 traffic from recycling endosomes to the Golgi.
"These data support a model where TBC1D14 acts as a bridge between a TRAPP complex and activated RAB11."
UniProtKB Q9P2M4 entry for TBC1D14