Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1.
Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption.
Megalin and cubilin: multifunctional endocytic receptors.
The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.
Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Amnionless-mediated glycosylation is crucial for cell surface targeting of cubilin in renal and intestinal cells.
Structural assembly of the megadalton-sized receptor for intestinal vitamin B(12) uptake and kidney protein reabsorption.
The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins.
Vitamin D (calciferol) metabolism
Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen
Endocytosis and degradation of apoA-I
CUBN:AMN binds CBLIF:RCbl
CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome
Defective CUBN does not transport GIF:Cbl
Defective AMN does not transport GIF:Cbl
LGMN hydrolyzes GC, releasing CUBN and 25(OH)D
LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D
Uptake of dietary cobalamins into enterocytes
UniProtKB entry O60494 (CUBN_HUMAN), Cubilin