Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation through association of UniProtKB keywords with GO terms
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on the InterPro2GO/ARBA mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.
Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.
Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.
Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast.
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.
Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
Human INT6/eIF3e is required for nonsense-mediated mRNA decay.
Results of the determination of serum markers in patients with malignant melanoma.
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.
The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.
Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.
A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay.
Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex.
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.
A UPF3-mediated regulatory switch that maintains RNA surveillance.
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay.
Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay.
Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1.
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA.
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans.
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition.
MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.
Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities.
Regnase-1 and Roquin regulate inflammatory mRNAs.
The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.
IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10.
UPF1-like helicase grip on nucleic acids dictates processivity.
Nonsense-mediated mRNA decay: The challenge of telling right from wrong in a complex transcriptome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.
Multimodal cell maps as a foundation for structural and functional genomics.
Mammalian orthologues of a yeast regulator of nonsense transcript stability.
Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein.
The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs.
Reactome: Formation of the SURF complex (cytosol)
Reactome: nonsense-mediated decay (cytosol)
Reactome: nonsense-mediated decay (cytosol)
Reactome: nonsense-mediated decay (cytosol)
Reactome: nonsense-mediated decay (cytosol)
Reactome: nonsense-mediated decay (cytosol)