SUN2 review notes

2026-09-27 (claude-code)

• Identity: human SUN2 / UNC84B / RAB5IP (Q9UH99), type II inner nuclear membrane protein, SUN-domain family.
• Core: SUN-KASH binding across the perinuclear space (LINC complex) PMID:18396275; trimeric SUN2 binds three KASH peptides PMID:22632968.
• Nucleoplasmic side: lamin A binding PMID:19933576.
• Neuronal nucleokinesis (mouse; redundant with SUN1) PMID:19874786.
• Decisions: GO:0034993 (meiotic LINC) rows MODIFY to non-meiotic parent GO:0106094 (evidence is mostly somatic nesprin-1/2/3 complexes); protein binding rows with nesprin partners MODIFY to GO:0140444, lamin rows to GO:0005521, HTP/viral/targeting-machinery rows REMOVE; TAS microtubule binding and mitotic spindle organization (from worm UNC-84 paper) REMOVE; endosome membrane (overexpressed rab5ip, PMID:10818110) MARK_AS_OVER_ANNOTATED.
• Deep research (falcon) consistent: SUN2 as non-catalytic LINC structural adaptor; 2023-2024 work on luminal disulfide regulation and nuclear actin/RNAPII coupling noted but not used for annotation.
• Module check (modules/nucleokinesis.yaml): GO:0140444 in nuclear inner membrane for SUN1/SUN2 and GO:0106094 LINC complex agree with this review.