Gene Ontology annotation through association of InterPro records with GO terms.
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic Gene Ontology annotation based on Rhea mapping.
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods.
Deep research report on gatC function and evolution
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GATC is a small protein (~100 amino acids) that serves as a critical structural scaffold and catalytic cofactor in the GatCAB heterotrimer
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GatCAB catalyzes transamidation of misacylated Glu-tRNA(Gln) to correctly charged Gln-tRNA(Gln)
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M. thermautotrophicus GatCAB exhibits unusual flexibility in amide donor specificity, using both Asn and Gln efficiently (kcat/KM of 5.7 and 16.7 s−1/mM respectively)
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M. thermautotrophicus GatCAB cannot transamidate homologous archaeal Glu-tRNA(Gln) but can work with bacterial Glu-tRNA(Gln)
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GATC is essential for stabilizing the GatA glutaminase domain and enabling its binding to GatB
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Pathogenic mutations in human GATC cause combined OXPHOS deficiency and metabolic cardiomyopathy
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GatCAB functions as a modulator of translational fidelity; reduced activity leads to increased mistranslation