Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Combined Automated Annotation using Multiple IEA Methods.
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.
BRCA1-associated growth arrest is RB-dependent.
VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells.
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1.
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.
Highlight: BRCA1 and BRCA2 proteins in breast cancer.
BRCA1 interacts directly with the Fanconi anemia protein FANCA.
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.
BRCA1 supports XIST RNA concentration on the inactive X chromosome.
MDC1 is a mediator of the mammalian DNA damage checkpoint.
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.
BRCA1 interacts with FHL2 and enhances FHL2 transactivation function.
The BRCT domain is a phospho-protein binding domain.
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.
BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention.
Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?
Structural determinants of the BRCA1 : estrogen receptor interaction.
BRCA1 participates in DNA decatenation.
Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.
BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.
ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells.
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.
The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.
CCDC98 targets BRCA1 to DNA damage sites.
E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.
Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.
CDK targets Sae2 to control DNA-end resection and homologous recombination.
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.
MERIT40 facilitates BRCA1 localization and DNA damage repair.
PALB2 is an integral component of the BRCA complex required for homologous recombination repair.
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.
Identification of DBC1 as a transcriptional repressor for BRCA1.
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.
BRCA1 affects global DNA methylation through regulation of DNMT1.
Transcriptional regulation of BRCA1 expression by a metabolic switch.
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.
Multifunctional transcription factor TFII-I is an activator of BRCA1 function.
KIAA0101 interacts with BRCA1 and regulates centrosome number.
Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses.
Toward an understanding of the protein interaction network of the human liver.
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair.
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
BRCA1:BARD1 heterodimer autoubiquitinates
Brca1 controls homology-directed DNA repair.
BRCA1 is associated with the centrosome during mitosis.
Gene Ontology annotation based on Enzyme Commission mapping
Gene Ontology annotation based on UniPathway vocabulary mapping.
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.
JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.
Roles of BRCA1 in centrosome duplication.
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene.
DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex.
Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity.
Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex.
BRCA1 is an essential regulator of heart function and survival following myocardial infarction.
BRCA1 tumor suppressor network: focusing on its tail.
FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.
BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis.
BRCA1 is a negative modulator of the PRC2 complex.
Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
EXD2 promotes homologous recombination by facilitating DNA end resection.
Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
Structural basis for regulation of human acetyl-CoA carboxylase.
CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.
The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1.
A protein interaction landscape of breast cancer.
BRCA1/BARD1 is a nucleosome reader and writer.
Identification of a RING protein that can interact in vivo with the BRCA1 gene product.
Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs.
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
Characterization of a carboxy-terminal BRCA1 interacting protein.
DNA Double Strand Break Response
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.
Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.
BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1).
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.
Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
A novel role for BRCA1 in regulating breast cancer cell spreading and motility.
Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations.
The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains.
PIAS1,4 SUMOylates BRCA1 with SUMO2,3
PIAS1,4 SUMOylates BRCA1 with SUMO1
BRCA1 forms a heterodimer with BARD1
Formation of BRCA1-A complex at DNA DSBs
CHEK2 is recruited to DNA DSBs
CHEK2 phosphorylates BRCA1
BRCA1 binds phosphorylated RBBP8
Binding of ATR:ATRIP to RPA at resected DNA DSBs
CHEK1 is recruited to resected DNA DSBs
Activation of CHEK1 at resected DNA DSBs
ATR activation at DNA DSBs
BCDX2 complex stabilizes RAD51 filament
CX3 complex binds D-loop structures
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
Long-range resection of DNA DSBs by EXO1 or DNA2
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
RAD52 promotes single strand annealing at resected DNA DSBs
ERCC1:XPF cleaves flaps generated by SSA
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
BRCA1-A complex deubiquitinates K63polyUb-histone H2A
Ligation of DNA and formation of Holliday structures following repair synthesis
Association of RPA complexes with ssDNA at resected DNA DSBs
Phosphorylation of BRCA1-A complex at multiple sites by ATM
RAD51 binds BRCA2 at resected DNA DSBs
Association of RAD51 with RAD52:DNA double-strand break ends
Association of RAD52 with the RPA complex at resected DNA DSBs
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
Initial resection of double-strand break ends
D-loop formation mediated by PALB2, BRCA2 and RAD51
CDK12 stimulates expression of DNA repair genes
Phosphorylation and activation of CHEK2 by ATM
BRCA1 gene expression is inhibited by E2F6
Some pathogenic BRCA1 mutants do not bind BARD1
Defective BARD1 does not bind BRCA1
BAP1 disrupts the BRCA1:BARD1 heterodimer
BAP1 binds BRCA1:BARD1 heterodimer
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C
UBXN1 binds BRCA1:BARD1 heterodimer
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
MITF-M-dependent BRCA1 gene expression
BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.
BRCA1 Mutational Complementation Induces Synthetic Viability.
Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Deep research on BRCA1 function