Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase.
Killing activity of neutrophils is mediated through activation of proteases by K+ flux.
UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin.
Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates.
Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production.
Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis.
Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins.
Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G.
The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase.
Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway.
Human neutrophil-derived elastase induces airway smooth muscle cell proliferation.
Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo.
Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis.
Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase.
Serine protease inhibitor 6-deficient mice have increased neutrophil immunity to Pseudomonas aeruginosa.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase.
Proteolysis of human thrombin generates novel host defense peptides.
Effect of plant neutrophil elastase inhibitor on leucocyte migration, adhesion and cytokine release in inflammatory conditions.
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps.
Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis.
Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.
Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Diverse stimuli engage different neutrophil extracellular trap pathways.
Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.
A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN).
Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death.
Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock.
Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction.
Neutrophil Elastase and Proteinase 3 Cleavage Sites Are Adjacent to the Polybasic Sequence within the Proteolytic Sensitive Activation Loop of the SARS-CoV-2 Spike Protein.
Primary structure of human neutrophil elastase.
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells.
Multimodal cell maps as a foundation for structural and functional genomics.
Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase.
Degradation of the extracellular matrix
Elastin degradation by elastin-degrading extracellular proteinases
Initial activation of proMMP1
Exocytosis of specific granule lumen proteins
Exocytosis of azurophil granule lumen proteins
ELANE, CTSG or PRTN3 binds bacteria
Cleavage of collagen type VIII by ELANE
Degradation of fibrilin-1 by Elane
Nid1 degradation by MMP1, 9, 12, ELANE