fadD1 (PA3299, Q9HYU4) review notes

Literature

Kang et al. 2010 (full text read, PMC2958839). fadD1 and fadD2 are genetically linked; both complement an E. coli fadD/fadR mutant PMID:21042406.
Purified FadD1 prefers long-chain fatty acids PMID:21042406; the enzymes were purified from an E. coli fadD- strain PMID:21042406.
Chromosomal mutants: PMID:21042406; PMID:21042406. The fadD1 mutant showed only increased swarming among virulence-related phenotypes; the mutants had reduced lung fitness in mice (not annotated; indirect).
Location: no data for FadD1; the paper's pathway model follows E. coli, where FadD is peripheral to the inner membrane PMID:21042406.

Other seed: E. coli FadD (P69451) checked in QuickGO (live, 2026-11-05): GO:0006631 IMP (PMID:1649829), GO:0004467 IDA/EXP, GO:0009898 IDA.

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN001534887	GO:0006631 fatty acid metabolic process	2	20 (10 taxa)	GO:0006631, IDA, PMID:21042406 (also GO:0042758 IDA, same paper)	SOUND	Purified-enzyme kinetics plus complemented mutant growth defects on fatty acids; the gene performs the activation step. The generic node term suits a clade of FadD-type AMP-binding acyl-CoA synthetases (FadD, FadD1, FadD2, RpfB and others).	E. coli FadD (P69451; GO:0006631 IMP, PMID:1649829)	Yes

No PSEUDOCAP or GO_CENTRAL defect.