Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:11854460

The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila.

Modulo binds dCBP in two-hybrid, GST pulldown and co-IP; Mod is predominantly nucleolar and binds polytene bands and heterochromatin.

PMID:1425581

Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila.

mod is a dominant suppressor of variegation; the protein binds DNA directly.

PMID:16877538

Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.

Modulo purified as the Sdic promoter-binding protein and required for spermatid differentiation gene transcription.

PMID:10037720

The Drosophila modifier of variegation modulo gene product binds specific RNA sequences at the nucleolus and interacts with DNA and chromatin in a phosphorylation-dependent manner.

Basic terminal domains bind DNA non-specifically; central RRM domain binds a motif-specific RNA class; phosphorylation down-regulates DNA binding; nucleolar Mod is in an RNP particle.

PMID:9718368

Dynamics of the sub-nuclear distribution of Modulo and the regulation of position-effect variegation by nucleolus in Drosophila.

Modulo is on condensed chromatin, heterochromatin and the nucleolus; DNA targets are repetitive elements, not rDNA.

PMID:12834864

Modulo is a target of Myc selectively required for growth of proliferative cells in Drosophila.

mod is a direct dMyc target required for growth of proliferative imaginal cells.

PMID:7813788

The modifier of variegation modulo gene acts downstream of dorsoventral and HOM-C genes and is required for morphogenesis in Drosophila.

PMID:23028777

A role for the CAL1-partner Modulo in centromere integrity and accurate chromosome segregation in Drosophila.

Modulo co-immunoprecipitates reciprocally with CAL1, is nucleolar but not centromeric, and its depletion reduces nucleolar CAL1, new CAL1 recruitment and centromeric CID, causing missegregation.

PMID:39700092

The RNA-binding protein Modulo promotes neural stem cell maintenance in Drosophila.

RIP-seq identifies Mod-bound transcripts; Mod is nucleolar in neuroblasts and needed for their maintenance.

PMID:39848495

Drosophila Modulo is essential for transposon silencing and developmental robustness.

Modulo interacts with Piwi in ovaries and is required for H3K9me3 deposition at a subset of Piwi-silenced transposons.

file:DROME/mod/mod-uniprot.txt

UniProt record P13469

file:DROME/mod/mod-deep-research-manual.md

Manual literature synthesis for mod