Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
UniProt entry A0A1J6JGR6 for Nicotiana attenuata FOX1_0
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FOX1_0 is a BBL-family FAD-linked oxidoreductase associated with nicotine biosynthesis
"Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine ... Catalyzes a late oxidation step subsequent to the pyridine ring condensation reaction in the biosynthesis of alkaloids."
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UniProt places FOX1_0 in the vacuole and assigns FAD cofactor use
"CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000256|ARBA:ARBA00004116}."
NaBBL1 FOX1_0 candidate notes
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BBL-family late-pathway biology is secure for FOX1_0-level paralog review
"The full preprint redefines BBLa as NicGS, the BBL-family enzyme that imposes stereoselective late-pathway chemistry in the nicotine synthase cascade, and supports that assignment with product-bound structural data."
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FOX1_0 remains a paralog-resolution candidate rather than a settled single-copy assignment
"For FOX1_0, that means the open question is paralog identity within the BBL family, not whether a BBL-like late oxidase matters in the pathway."