Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.
Zebrafish Smad7 is regulated by Smad3 and BMP signals.
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Smad3b induces mesoderm and activates organizer genes such as goosecoid when overexpressed.
"We show that zebrafish Smad3b, in contrast to the related zebrafish Smad2, can induce mesoderm independently of TGF-beta signaling."
smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafish.
Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish.
dickkopf-3-related gene regulates the expression of zebrafish myf5 gene through phosphorylated p38a-dependent Smad4 activity.
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Smad3b plays only a minor role in myf5 promoter activation compared with Smad2 and Smad3a.
"Although the ability of Smad2 and Smad3a to activate the myf5 promoter requires Smad4 to form a complex and enter the nucleus, Smad3b only plays a minor role in myf5 promoter activation."
A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development.
Evolution history of duplicated smad3 genes in teleost: insights from Japanese flounder, Paralichthys olivaceus.
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Teleost smad3b evolves faster than smad3a and has linker sites under positive selection.
"Five candidate positive selected sites were identified, two of which were significantly positively selected (219L**, 221L**, posterior probability > 0.99) in smad3b."
Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair.
Interactions between the circadian clock and TGF-β signaling pathway in zebrafish.
Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?
Smad3 deficiency attenuates disease severity in a zebrafish model for Smad6-related aortic disease.
smad3a/smad3b/human SMAD3/gar SMAD3 protein comparison and Bgee/ZFIN expression comparison