Doc1 (Dorsocross1, Q9U8L5, unreviewed TrEMBL) — curation notes

Automated deep research was unavailable (falcon 402, OpenAI 401); no -deep-research-<provider>.md
generated. Notes from cached publications and UniProt.

Identity and redundancy

• T-box, Tbx6-related; Doc1/2/3 clustered and redundant
  PMID:12783790;
  PMID:14732398.
  Most loss-of-function data use deficiencies (Df(3L)DocA) removing all three genes or pan-Doc RNAi;
  annotations from such data apply to the Doc paralogs collectively.

Molecular function

• Binds Toll dorsal vessel enhancer PMID:15870289 (full text); activator.
• Represses reaper HRE through a mapped site PMID:19282966 (full text).

Development

• Amnioserosa PMID:12783790.
• Heart: PMID:16221729;
  activates pannier with tinman; later ostia PMID:16221729;
  Tin restricts Doc to ostial cells PMID:16987868.
• Wing disc primordium PMID:14732398; anterior Malpighian tubules PMID:17190812; thorax closure PMID:35562934.

Curation decisions

• GO:0001700 -> MODIFY to GO:0046665 amnioserosa maintenance; NEW GO:0046665 IMP PMID:12783790.
• GO:0010468 -> MODIFY to GO:0000122 (rpr repression via binding site).
• GO:0160108 ARBA -> MARK_AS_OVER_ANNOTATED (uninformative).
• GO:0007507 TAS from Hox review (abstract lacks Doc) -> ACCEPT on primary evidence.
• Module annoton GO:0000981 in heart development: consistent. Note no evidence of Doc physically binding Tin/Pnr in flies (the module's TBX5-NKX2-5 interaction is vertebrate-only).