Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.
Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes.
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The paper assays envelope composition. Its separately recovered original Table 2 identifies DSP-derived material, without demonstrating DSP performing cross-link formation.
"protein composition of cell envelopes (CEs)"
Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
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The PKP2 head domain is important for its desmosomal partner interactions. The separately recovered original Figure 6 also directly compares DSP-NTP binding to PKP1a and PKP2a; that PKP1 result is not inferred from this abstract anchor.
"The head domain of plakophilin 2 is critical for most of these interactions"
Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy.
Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.
Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Increased keratinocyte proliferation initiated through downregulation of desmoplakin by RNA interference.
P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3.
Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
The desmoglein-specific cytoplasmic region is intrinsically disordered in solution and interacts with multiple desmosomal protein partners.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly.
Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.
Proteomic characterization of the human sperm nucleus.
The nonlinear structure of the desmoplakin plakin domain and the effects of cardiomyopathy-linked mutations.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.
Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy.
Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy.
Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation.
Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions.
GSK3- and PRMT-1-dependent modifications of desmoplakin control desmoplakin-cytoskeleton dynamics.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome.
SVEP1 plays a crucial role in epidermal differentiation.
Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.
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Endogenous DSP co-immunoprecipitates contain COPS3 in human keratinocytes; separate tail-capture and controlled proximity assays corroborate the association.
"Cops3 was also present in immunoprecipitates of endogenous Dp"
Nuclear localization of Desmoplakin and its involvement in telomere maintenance.
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Human cell co-immunoprecipitation supports DSP–TERF2 association, with NLS-dependent nuclear scope and TRF2-dependent telomeric DSP signals.
"TRF2 interacts with DSP in both HEK293 and MCF-7 cells"
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma.
Caspase-mediated cleavage of Desmoplakin
Exocytosis of ficolin-rich granule membrane proteins
Keratin filaments bind cell-cell adhesion complexes
Fillagrin and keratin intermediate filaments polymerize forming a network
Lamellar bodies bind the early cornified envelope
Reinforcement of the Cornified Envelope
Late envelope proteins bind cornified envelope:CDSN
CDSN binds the cornified envelope
Plasma membrane resorption
Filaggrin binds Keratin tonofilament:Desmosome
Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature.
Desmoplakin is essential in epidermal sheet formation.
Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells.
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.
The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins.
Desmoplakin: an unexpected regulator of microtubule organization in the epidermis.
Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors.
Desmoplakin is involved in organization of an adhesion complex in peripheral nerve regeneration after injury.
A recessive mutation in the DSP gene linked to cardiomyopathy, skin fragility and hair defects impairs the binding of desmoplakin to epidermal keratins and the muscle-specific intermediate filament desmin.
Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.
Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells affects germ cell survival in developing mouse gonads.
The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes.
Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage.
Tyrosine-protein kinase Fes/Fps
Microtubule-associated protein RP/EB family member 1
Subcellular - DSP - The Human Protein Atlas
Caracterització del contingut proteic del nucli de l’espermatozoïde humà i el seu potencial epigenètic
DSP source-derived measurement records
DSP source-derived Reactome membership paths