Gene Ontology annotation through association of InterPro records with GO terms

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:19914232

Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity.

Mouse Foxj3 binds a conserved forkhead binding site in the Mef2c skeletal-muscle enhancer and activates it dose-dependently; the C-terminal region beyond residue 176 carries transactivation activity; Foxj3 mutant mice have fewer type I myofibers and impaired regeneration.

"Foxj3 transcriptionally activates the Mef2c gene in a dose dependent fashion and binds to the conserved FBS"

PMID:27739607

Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.

Germ-cell conditional deletion of mouse Foxj3 causes loss of spermatogonia or meiotic arrest, with reduced mRNA of meiotic genes.

"we conclude that FOXJ3 is required for the survival of spermatogonia and participates in spermatocyte meiosis"

PMID:15366017

FoxJ3, a novel mammalian forkhead gene expressed in neuroectoderm, neural crest, and myotome.

Mouse Foxj3 is a 13-exon gene encoding a 623-aa protein most closely related to FoxJ2.

"It is most closely related to FoxJ2 and has been assigned the name FoxJ3."

PMID:37939221

Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via Induction of PGC-1α.

Adipose-specific Foxj3 deletion impairs brown-fat thermogenesis; Foxj3 induces PGC-1alpha and UCP1 expression.

"cold-inducible Foxj3 stimulated the expression of PGC-1α and UCP1"

PMID:41803108

Epilepsy-associated FOXJ3 variants link a transcriptional program of the PTEN-mTOR pathway to neuronal specification and cortical lamination.

FOXJ3 ChIP-seq identifies Pten as a target in developing mouse cortex; human FOXJ3 variants associate with focal epilepsy and focal cortical dysplasia.

"ChIP-seq and scRNA-seq analyses identify Pten as a key FOXJ3 target."

PMID:40522413

Foxj3 represses TGF-β signals-responsive transcriptions in Xenopus early development.

Xenopus Foxj3 represses Activin/Nodal- and BMP-responsive transcription.

"Foxj3 was found to regulate negatively the transcription of target genes induced by Activin/Nodal or BMP signal in Xenopus embryos"

file:EQUAS/FOXJ3/FOXJ3-bioinformatics/RESULTS.md

FOXJ3: donkey-human sequence comparison

file:EQUAS/FOXJ3/FOXJ3-bioinformatics/RESULTS-rereview.md

FOXJ3 (donkey): benchmark model versus full-length gene model (re-review, 2026-10-21)

file:EQUAS/FOXJ3/FOXJ3-bioinformatics/human-Q9UPW0-uniprot.txt

UniProtKB/Swiss-Prot record Q9UPW0 (human FOXJ3), downloaded 2026-10-14

file:EQUAS/FOXJ3/FOXJ3-bioinformatics/donkey-A0A8C4PFN5-uniprot.txt

UniProtKB/TrEMBL record A0A8C4PFN5 (donkey FOXJ3, 623 aa), downloaded 2026-10-21