Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach.
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases.
An efficient mammalian cell-free translation system supplemented with translation factors.
Intersubunit and interprotein interactions of alpha- and beta-subunits of human eIF2: Effect of phosphorylation.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Architecture of the human interactome defines protein communities and disease networks.
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Binding of human Cdc123 to eIF2γ.
Multimodal cell maps as a foundation for structural and functional genomics.
Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit.
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
Formation of translation initiation complexes containing mRNA that does not circularize
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
eIF2:GTP is hydrolyzed, eIFs are released
De novo formation of eIF2:GTP
Met-tRNAi binds to eIF2:GTP to form the ternary complex
Formation of eIF2:GDP:eIF2B intermediate
Formation of the 43S pre-initiation complex
p-PKR dimer phosphorylates eIF2-alpha
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)
MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNAiMet binding to eukaryotic translation initiation factor eIF2.
Stepwise assembly of the eukaryotic translation initiation factor 2 complex.
A comparative study of the characteristics of eIF-2 and eIF-2-ancillary factor activities from yeast Saccharomyces cerevisiae and rabbit reticulocytes.