Gene Ontology annotation through association of InterPro records with GO terms.
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Combined Automated Annotation using Multiple IEA Methods.
The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress.
Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.
Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay.
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.
Defining the membrane proteome of NK cells.
The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Reduction of desmosterol to cholesterol
Cholesterol biosynthesis via desmosterol
Cholesterol biosynthesis via lathosterol
DHCR24 reduces ZYMOL to ZYMSTNL
DHCR24 reduces LAN to 24,25-dhLAN
The membrane topological analysis of 3β-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum.
Generation of viable cholesterol-free mice.
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes.
The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo.
DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis.
DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling.
Seladin-1 expression in rat adrenal gland: effect of adrenocorticotropic hormone treatment.
DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme.
UniProtKB reviewed entry Q15392 (DHC24_HUMAN)